Pdx1 (D59H3) XP? Rabbit mAb

• 产品编号：CST-5679S      品牌：CST       原厂货号：5679S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Pdx1 (D59H3) XP® Rabbit mAb兔单抗用于检测内源性Pdx1总蛋白水平。胰腺十二指肠同源框基因1(Pdx1)是胰腺发育，β细胞分化和成熟β细胞功能的一个转录因子（1,2）。它在内胚层向胰腺以及随后的β细胞发育过程中起着关键的作用（2,3）。在成熟的胰腺组织中，Pdx1的表达仅局限于胰岛β细胞中（3），它可以促进β细胞多种功能基因的表达，如胰岛素，萄糖激酶和Glut2(4-6)。Pdx1基因的突变跟糖尿病和胰岛功能缺失相关（7）。

1. Kaneto, H. et al. (2008) Endocr J 55, 235-52.
2. Habener, J.F. et al. (2005) Endocrinology 146, 1025-34.
3. Guz, Y. et al. (1995) Development 121, 11-8.
4. Ohlsson, H. et al. (1993) EMBO J 12, 4251-9.
5. Watada, H. et al. (1996) Diabetes 45, 1826-31.
6. Waeber, G. et al. (1996) Mol Endocrinol 10, 1327-34.
7. Cockburn, B.N. et al. (2004) J Clin Endocrinol Metab 89, 971-8.

原厂资料：

Specificity / Sensitivity

Pdx1 (D59H3) XP® Rabbit mAb detects endogenous levels of total Pdx1 protein.

Source / Purification

Pdx1 (D59H3) XP® Rabbit mAb detects endogenous levels of total Pdx1 protein.

Description

Pdx1 (D59H3) XP® Rabbit mAb detects endogenous levels of total Pdx1 protein.

Background

The pancreatic duodenal homeobox gene-1 (Pdx1) is a transcription factor that contributes to pancreas development, pancreatic β-cell differentiation, and mature β-cell function (1,2). It plays an essential role in the commitment of endoderm to a pancreatic and later β-cell phenotype (2,3). In the mature pancreas, Pdx1 expression is more restricted to the pancreatic β-cells (3), where it promotes the expression of genes important for β-cell functions such as insulin, glucokinase, and Glut2 (4-6). Mutations of the corresponding Pdx1 gene may be associated with diabetes and cases of pancreatic insufficiency (7).

1. Kaneto, H. et al. (2008) Endocr J 55, 235-52.
2. Habener, J.F. et al. (2005) Endocrinology 146, 1025-34.
3. Guz, Y. et al. (1995) Development 121, 11-8.
4. Ohlsson, H. et al. (1993) EMBO J 12, 4251-9.
5. Watada, H. et al. (1996) Diabetes 45, 1826-31.
6. Waeber, G. et al. (1996) Mol Endocrinol 10, 1327-34.
7. Cockburn, B.N. et al. (2004) J Clin Endocrinol Metab 89, 971-8.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody