Drebrin (pan) Antibody recognizes endogenous levels of total DrebrinE and DrebrinA proteins.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu580 of human Drebrin protein. Antibodies are purified by protein A and peptide affinity chromatography.
原厂资料：
Specificity / Sensitivity
Drebrin (pan) Antibody recognizes endogenous levels of total DrebrinE and DrebrinA proteins.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu580 of human Drebrin protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Developmentally-regulated brain proteins (Drebrins) are cytoplasmic proteins that were originally identified in the brain as F-actin-binding proteins. There are two mammalian isoforms: adult type (A) and embryonic type (E). These isoforms are derived from a single gene through alternative RNA splicing mechanisms (1). DrebrinE has been observed to accumulate in the developmental stage of migrating neurons and in the growing cell processes of neurons. DrebrinA is found at the dendritic spines of mature cortical neurons where it plays a role in synaptic plasticity (2,3). Although drebrins are primarily found in neurons, they have also been found in skeletal muscle, heart, pancreas, and kidney. Research studies have shown that reduced expression of drebrin in the brain could be associated with Alzheimer’s Disease, Down Syndrome (4), and bipolar disorders (5).
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