Integrin β1 Antibody detects endogenous levels of total integrin β1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro680 of human integrin β1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2). The β1 subfamily includes 12 distinct intergrin proteins that bind to different extracellular matrix molecules (4). Control of extracellular integrin binding influences cell adhesion and migration, while intracellular signaling messages relayed by the β1 cytoplasmic tail helps to regulate cell proliferation, cytoskeletal reorganization and gene expression (4). β1 integrin is implicated in various activities including embryonic development, blood vessel, skin, bone and muscle formation, as well as tumor metastasis and angiogenesis (4,5).
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