Parkin (Prk8) Mouse mAb detects endogenous levels of total parkin protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with human recombinant parkin and the epitope maps to the carboxy terminus of the protein.
Background
Parkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box (1). In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin (2).