FAAH1 (C84F1) Rabbit mAb

• 产品编号：CST-3829S      品牌：CST       原厂货号：3829S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

FAAH1 (C84F1) Rabbit mAb兔单抗用于检测内源性FAAH1总蛋白水平.单克隆抗体通过用对应于人源FAAH1蛋白序列的合成肽免疫动物制备而得。内源性大麻素在成瘾行为如毒品成瘾中起着作用(1)。脂肪酸酰胺水解酶1(FAAH1)是一种膜结合水解酶，负责将油酸酰胺转化成油酸(2)。该酶同样也可以将大麻素(作为内源性CB1大麻素受体的配体)转变成大麻酸，这暗示它可以在脂肪酸酰胺的失活中发挥着某些作用(2)。FAAH1缺失小鼠的大脑中大麻素的水平显著上升，并且表现出对疼痛的不敏感，这进一步提示FAAH1可能调控着内源性大麻素信号通路(3)。与野生型小鼠相比，FAAH1缺失小鼠表现出对酒精的偏好，并且会自觉的增加对酒精的摄入，这暗示FAAH1在调节成瘾行为中起着某些作用(1)。

1. Blednov, Y.A. et al. (2007) Neuropsychopharmacology 32, 1570-82.
2. Cravatt, B.F. et al. (1996) Nature 384, 83-7.
3. Cravatt, B.F. et al. (2001) Proc Natl Acad Sci USA 98, 9371-6.

原厂资料：

Specificity / Sensitivity

FAAH1 (C84F1) Rabbit mAb detects endogenous levels of total FAAH1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues from the sequence of human FAAH1 protein.

Background

Endogenous cannabinoids have been implicated in addictive behaviors and drug abuse (1). Fatty-acid amide hydrolase 1 (FAAH1) is a plasma membrane-bound hydrolase that converts oleamide to oleic acid (2). This hydrolase also converts the cannabinoid anandamide, the endogenous ligand for the CB1 cannabinoid receptor, to arachidonic acid, suggesting a role in fatty-acid amide inactivation (2). Mice lacking FAAH1 have significantly higher levels of anandamide in the brain and show decreased sensitivity to pain, further indicating a role for FAAH1 in the regulation of endocannabinoid signaling in vivo (3). FAAH1 null mice also demonstrate an increased preference for alcohol and an increased voluntary uptake of alcohol as compared to wild-type mice, indicating a role of FAAH1 in modulating addictive behaviors (1).

1. Blednov, Y.A. et al. (2007) Neuropsychopharmacology 32, 1570-82.
2. Cravatt, B.F. et al. (1996) Nature 384, 83-7.
3. Cravatt, B.F. et al. (2001) Proc Natl Acad Sci USA 98, 9371-6.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.