Integrin α6 Antibody

• 产品编号：CST-3750S      品牌：CST       原厂货号：3750S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Integrin α6抗体检测内源性总的Integrin α6蛋白。多克隆抗体由合成肽段免疫动物产生，该合成肽段与人Integrin α6蛋白的571位甘氨酸附件残基相对应，抗体由肽段亲和层析技术纯化。Integrins是α/β异源二聚细胞表面受体，在细胞粘附和迁移，还有增长和存活中起关键作用（1,2）.整合素家族含至少18个α和8个β亚单元，可形成24个已知的整合素，它们带有独特组织分布特性和重叠的配基特异性（3）。整合素不仅在受到胞外环境刺激下，传递信号到细胞（由外而内信号），而且感知胞内因素来改变它们与胞外环境的相互作用(内到外的信号)（1,2）。整合素α6是一个120kDa蛋白，带有两个剪接异构体， integrin α6, 6A 和 6B（3）它们在基底膜上起功能作为laminins的受体，调节粘附活动（4-6）。α6 integrins已经显示在造血干细胞和祖细胞归巢到骨髓中起重要作用。

1. Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.
2. Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
3. Hogervorst, F. et al. (1993) J Cell Biol 121, 179-91.
4. Sonnenberg, A. et al. (1990) J Cell Biol 110, 2145-55.
5. Sonnenberg, A. et al. (1993) J Cell Sci 106 ( Pt 4), 1083-102.
6. Shaw, L.M. et al. (1990) J Cell Biol 110, 2167-74.

原厂资料：

Specificity / Sensitivity

Integrin α6 Antibody detects endogenous levels of total integrin α6 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding residues surrounding Gly571 of human integrin α6. Antibodies are purified by peptide affinity chromatography.

Background

Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). 
 Integrin α6 is a 120 kDa protein with two splice variants, integrin α6, 6A and 6B (3), which function as receptors for laminins on the basal membrane to mediate cellular adhesion events (4-6). α6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow.

1. Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.
2. Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
3. Hogervorst, F. et al. (1993) J Cell Biol 121, 179-91.
4. Sonnenberg, A. et al. (1990) J Cell Biol 110, 2145-55.
5. Sonnenberg, A. et al. (1993) J Cell Sci 106 ( Pt 4), 1083-102.
6. Shaw, L.M. et al. (1990) J Cell Biol 110, 2167-74.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.