PHF2 (D45A2) Rabbit mAb

• 产品编号：CST-3497S      品牌：CST       原厂货号：3497S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

PHF2 (D45A2) Rabbit mAb兔单抗能够检测内源性PHF2总蛋白水平。通过合成的与人源PHF2蛋白去免疫动物从而制备出单克隆抗体。Plant homeodomain (PHD) finger protein 2 (PHF2)是一个转录因子。PHF2包含一个锌指样PHD结构域，它与其它锌指结构有明显区别，并且经常发现在影响染色质结构的蛋白质中(1)。它也包含一个Jumonji C (JmjC)结构域，它可能在组蛋白去甲基化中起着重要作用(2)。PHF2基因在成年小鼠组织中广泛表达；然而，在小鼠胚胎中多数PHF2蛋白表达发生在神经管和根神经节(1)。PHF2突变是与早期和晚期乳腺癌有关联(3)。

1. Hasenpusch-Theil, K. et al. (1999) Mamm Genome 10, 294-8.
2. Klose, R.J. et al. (2006) Nat Rev Genet 7, 715-27.
3. Sinha, S. et al. (2008) Mol Cancer 7, 84.

原厂资料：

Specificity / Sensitivity

PHF2 (D45A2) Rabbit mAb detects endogenous levels of total PHF2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the human PHF2 protein.

Background

Plant homeodomain (PHD) finger protein 2 (PHF2) is a putative transcription factor. PHF2 contains a zinc finger-like PHD domain that is distinct from other classes of zinc finger motifs and is often found in proteins that influence chromatin structure (1). It also contains a Jumonji C (JmjC) domain, which may play a role in histone demethylation (2). The PHF2 gene is ubiquitously expressed in adult mouse tissues; however, the majority of PHF2 expression in the mouse embryo occurs in the neural tube and root ganglia (1). PHF2 mutations have been associated with both early- and late-onset breast carcinoma (3).

1. Hasenpusch-Theil, K. et al. (1999) Mamm Genome 10, 294-8.
2. Klose, R.J. et al. (2006) Nat Rev Genet 7, 715-27.
3. Sinha, S. et al. (2008) Mol Cancer 7, 84.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.