Pan-Keratin (C11) Mouse mAb (Alexa Fluor? 555 Conjugate)

产品编号：CST-3478S 品牌：CST 原厂货号：3478S
产品分类：抗体 > 一抗 > 染料标记抗体
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包装：

运保温度:

4ºC

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描述：

Specificity / Sensitivity

Pan-Keratin (C11) Mouse mAb (Alexa Fluor^®555 Conjugate) detects endogenous levels of total keratins 4, 5, 6, 8, 10, 13 and 18. The antibody does not cross-react with other keratins.

原厂资料：

Specificity / Sensitivity

Pan-Keratin (C11) Mouse mAb (Alexa Fluor^®555 Conjugate) detects endogenous levels of total keratins 4, 5, 6, 8, 10, 13 and 18. The antibody does not cross-react with other keratins.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a cytoskeleton preparation from A-431 cells. The antibody was conjugated to Alexa Fluor® 555 under optimal conditions with an F/P ratio of 2-6.

Product Description

This Cell Signaling Technology antibody is conjugated to Alexa Fluor^® 555 fluorescent dye and tested in-house for immunofluroescent analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated Pan-Keratin (C11) Mouse mAb #4545.

Background

Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).

1. Moll, R. et al. (1982) Cell 31, 11-24.

2. Chang, L. and Goldman, R.D. (2004) Nat Rev Mol Cell Biol 5, 601-13.

3. Ramaekers, F.C. and Bosman, F.T. (2004) J Pathol 204, 351-4.

4. Lane, E.B. and McLean, W.H. (2004) J Pathol 204, 355-66.

5. Zatloukal, K. et al. (2004) J Pathol 204, 367-76.

6. Owens, D.W. and Lane, E.B. (2004) J Pathol 204, 377-85.

注意事项：

Storage: Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.