Endoglin Antibody (Mouse Specific)

• 产品编号：CST-3290S      品牌：CST       原厂货号：3290S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Endoglin抗体（小鼠特异）识别转染水平的Endoglin蛋白.多克隆抗体是通过一种合成的肽段去免疫动物产生。这种合成的肽段与邻近人源endoglin蛋白的Pro430氨基酸残基序列一致，抗体由蛋白A和肽段亲和层析技术纯化.Endoglin(ENG, CD105)是TGF-β受体复合物的辅助受体，在相关信号通路中起作用（1,2）。Endoglin是一种跨膜蛋白，以二硫键连接的二聚体形式存在。主要在血管和连接性组织，上皮和间质细胞总表达。上调的Endoglin表达在伤口愈合和肿瘤血管生成，发炎组织和发育的胚胎中被报道，（1-4）。Endoglin的突变已在遗传性出血性血管扩张（HHT）被认为是一种偶然因素，HHT是一种以血管畸形结构为特点的疾病（5,6）。这种蛋白对正常和肿瘤血管功能的重要性使得它成为上皮细胞增殖的重要标志物，也是对癌症的潜在药物靶标（4-6）.

1. Bernabeu, C. et al. (2007) J Cell Biochem 102, 1375-88.
2. Zhu, Y. et al. (2003) Stroke 34, 2483-8.
3. Quintanilla, M. et al. (2003) Oncogene 22, 5976-85.
4. Dallas, N.A. et al. (2008) Clin Cancer Res 14, 1931-7.
5. ten Dijke, P. et al. (2008) Angiogenesis 11, 79-89.
6. Fernández-L, A. et al. (2006) Clin Med Res 4, 66-78.

原厂资料：

Specificity / Sensitivity

Endoglin Antibody (Mouse Specific) detects transfected levels of mouse endoglin protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro430 of mouse endoglin. Antibodies are purified by peptide affinity chromatography.

Background

Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6).

1. Bernabeu, C. et al. (2007) J Cell Biochem 102, 1375-88.
2. Zhu, Y. et al. (2003) Stroke 34, 2483-8.
3. Quintanilla, M. et al. (2003) Oncogene 22, 5976-85.
4. Dallas, N.A. et al. (2008) Clin Cancer Res 14, 1931-7.
5. ten Dijke, P. et al. (2008) Angiogenesis 11, 79-89.
6. Fernández-L, A. et al. (2006) Clin Med Res 4, 66-78.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody