PDK1 Antibody

产品编号：CST-3062P 品牌：Cell Signaling Technology 原厂货号：3062P
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

40 ul

运保温度:

–20°C.

到货周期：

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描述：

PDK1 Antibody能够检测内源性的PDK1总蛋白。该多克隆抗体是由合成的人源PDK1蛋白氨基末端序列的肽段免疫动物而生产的。抗体由protein A和肽亲和层析技术纯化。磷酸肌醇依赖蛋白激酶1（PDK1）在多种信号传导通路中发挥核心作用（1,2），包括Akt和PKC同工酶p70 S6激酶和RSK的活化（3）。通过这些激酶，PDK1参与调控了广泛的生物学过程，包括细胞增殖，分化和凋亡。

原厂资料：

Specificity / Sensitivity

PDK1 Antibody detects endogenous levels of total PDK1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the carboxy terminus of human PDK1. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Phosphoinositide-dependent protein kinase 1 (PDK1) plays a central role in many signal transduction pathways (1,2) including the activation of Akt and the PKC isoenzymes p70 S6 kinase and RSK (3). Through its effects on these kinases, PDK1 is involved in the regulation of a wide variety of processes, including cell proliferation, differentiation and apoptosis.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.