Heregulin Antibody

• 产品编号：CST-2573S      品牌：CST       原厂货号：2573S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Heregulin抗体可以识别内源性的总Heregulin蛋白。此抗体与其他蛋白家族成员没有交叉反应。合成对应人Heregulin 494位组氨酸的邻近氨基酸残基序列的多肽免疫动物获得多克隆抗体。抗体由蛋白A和肽段亲和层析技术纯化。Heregulin (HRG，神经生成因子)也称为neuregulin (NRG1神经调节蛋白)，neu differentiation factor (NDF，神经分化因子)或glial growth factor-2 (GGF-2，神经胶质生长因子-2)，是一种由原始跨膜分子合成的可溶性生长因子。金属蛋白酶和其他蛋白酶催化其细胞外区域的裂解，随后释放并作为ErbB3 和ErbB4酪氨酸激酶受体的配体发挥功能。HRG-ErbB3/ErbB4信号通路涉及正常及恶性组织中细胞增殖，分化，侵袭和生存的调控（1,2）。HRG-ErbB信号通路异常会导致多种人体疾病的发生。HRG家族有4个亚型，包括HRG-1,-2,-3和-4，来自于选择性外显子剪切。此外，他们在多种组织中表达并有不同的生物学功能（3）。

1. Breuleux, M. (2007) Cell Mol Life Sci 64, 2358-77.
2. Ozaki, M. et al. (2004) J Neurochem 91, 176-88.
3. Falls, D.L. (2003) Exp Cell Res 284, 14-30.

原厂资料：

Specificity / Sensitivity

Heregulin Antibody detects endogenous levels of total heregulin proteins. The antibody does not cross-react with other family members.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His494 of human heregulin. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Heregulin (HRG), also called neuregulin (NRG1), neu differentiation factor (NDF) or glial growth factor-2 (GGF-2), is a soluble growth factor synthesized as a transmembrane precursor molecule. Metalloproteinases and other proteases catalyze the cleavage of its extracellular domain which is then released and functions as a ligand for ErbB3 and ErbB4 receptor tyrosine kinase. The signaling pathways of HRG-ErbB3/ErbB4 are involved in regulation of cell proliferation, differentiation, invasion, and survival of both normal and malignant tissues (1,2). Abnormality of HRG-ErbB signaling leads to development of a variety of human diseases. 
 HRG family has four isoforms including HRG-1, -2, -3 and -4, which are derived from alternative exon splicing. Moreover, they showed various tissue expression and biological activities (3).

1. Breuleux, M. (2007) Cell Mol Life Sci 64, 2358-77.
2. Ozaki, M. et al. (2004) J Neurochem 91, 176-88.
3. Falls, D.L. (2003) Exp Cell Res 284, 14-30.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody