AP-2γ Antibody

• 产品编号：CST-2320S      品牌：CST       原厂货号：2320S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

AP-2γ Antibody 能够检测内源AP-2γ总蛋白。该多克隆抗体是采用合成的人源 AP-2γ 序列对应的多肽来免疫动物而获得。抗体是通过protein A和多肽亲和层析法纯化。

激活因子蛋白2γ (AP-2γ)是发育调控转录因子激活蛋白2家族的成员之一(1)。在人乳腺癌细胞中过表达p53，能增加AP-2γ mRNA 和蛋白的表达量(2)。另外, p53结合到AP-2γ启动子上, 表明了p53是AP-2γ的标靶之一。因此，AP-2γ可能对p53介导的生长抑制有作用(2)。研究也表明了，AP-2γ增加p21 mRNA和蛋白的水平，并诱导细胞周期停在G1时期(3)。过表达AP-2γ抑制人类乳腺癌细胞的生长(3)。综上所述, 这些研究表明AP-2γ是作为肿瘤抑制因子而起作用(3)。

1. Hasleton, M.D. et al. (2003) Biochem. J. 373, 925-932.
2. Li, H. et al. (2006) Oncogene 25, 5405-5415.
3. Li, H. et al. (2006) Neoplasia 8, 568-577.

原厂资料：

Specificity / Sensitivity

AP-2γ Antibody detects endogenous levels of total AP-2γ protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human AP-2γ. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Activator protein 2γ (AP-2γ) is a member of the developmentally-regulated transcription factor activator protein 2 family (1). Overexpression of p53 in human breast cancer cells increases AP-2γ mRNA and protein (2). In addition, p53 binds to the AP-2γ promoter, suggesting that AP-2γ is a target of p53. AP-2γ therefore may contribute to p53-mediated growth inhibition (2). Studies also found that AP-2γ increases p21 mRNA and protein levels and induces cell-cycle arrest in G1 phase (3). Overexpression of AP-2γ inhibits the growth of human breast cancer cells (3). Taken together, these findings suggest that AP-2γ functions as a tumor suppressor (3).

1. Hasleton, M.D. et al. (2003) Biochem. J. 373, 925-932.
2. Li, H. et al. (2006) Oncogene 25, 5405-5415.
3. Li, H. et al. (2006) Neoplasia 8, 568-577.

注意事项：

For Research Use Only. Not For Use In Diagnostic Procedures.

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.