EB-1 (1A11/4) Mouse mAb

• 产品编号：CST-2164S      品牌：CST       原厂货号：2164S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

EB-1 (1A11/4) Mouse mAb检测内源性EB-1蛋白。通过重组人源EB-1蛋白去免疫CD-1小鼠从而制备出单克隆抗体。EB1 (end-binding protein 1)蛋白是一个微管相关蛋白 (1)。EB1蛋白停留在微管、中心体和有丝分裂纺锤体的生长末端(2-4)。EB1蛋白也发现与adenomatous polyposis coli (APC)蛋白联系(5)。最近研究也发现EB1蛋白在基于微管运输中起着重要角色(6)。

1. Tirnauer, J.S. and Bierer, B.E. (2000) J. Cell Biol. 149, 761-766.
2. Vaughan, K.T. (2005) J. Cell Biol. 171, 197-200.
3. Berrueta, L. et al. (1998) Proc. Natl. Acad. Sci. USA 95, 10596-10601.
4. Morrison, E.E. et al. (1998) Oncogene 17, 3471-3477.
5. Su, L.K. et al. (1995) Cancer Res. 55, 2972-2977.

原厂资料：

Specificity / Sensitivity

EB-1 (1A11/4) Mouse mAb detects endogenous levels of EB-1.

Source / Purification

Monoclonal antibody is produced by immunizing CD-1 mice with a recombinant human EB-1 protein.

Background

EB1 (end-binding protein 1) is a microtubule associated protein (1). EB1 localizes to the growing ends of microtubules, the centrosome and the mitotic spindle (2-4). EB1 is also found to associate with the adenomatous polyposis coli (APC) protein (5). Recent studies also suggest that EB1 plays a role in microtubule-based transport (6).

1. Tirnauer, J.S. and Bierer, B.E. (2000) J. Cell Biol. 149, 761-766.
2. Vaughan, K.T. (2005) J. Cell Biol. 171, 197-200.
3. Berrueta, L. et al. (1998) Proc. Natl. Acad. Sci. USA 95, 10596-10601.
4. Morrison, E.E. et al. (1998) Oncogene 17, 3471-3477.
5. Su, L.K. et al. (1995) Cancer Res. 55, 2972-2977.

注意事项：

For Research Use Only. Not For Use In Diagnostic Procedures.

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.