SGLT2 Antibody

• 产品编号：CST-14210S      品牌：CST       原厂货号：14210S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Specificity / Sensitivity

SGLT2 Antibody recognizes endogenous levels of total SGLT2 protein. This antibody does not recognize SGLT1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human SGLT2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Specificity / Sensitivity

SGLT2 Antibody recognizes endogenous levels of total SGLT2 protein. This antibody does not recognize SGLT1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human SGLT2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Na(+)/glucose cotransporter 2 (SGLT2) is one of the two main glucose transporters in the kidney proximal convoluted tubule. It is activated by Protein Kinase A and Protein Kinase C, likely through phosphorylation of Ser624 (1,2). SGLT2 is responsible for the majority of glucose reabsorption in the kidney (3,4), and mutations in SGLT2 are known to cause familial renal glucosuria (5,6). SGLT2 is a therapeutic target for type 2 diabetes. Inhibitors of SGLT2 have been developed in order to treat people with type 2 diabetes (7).

1. Feric, M. et al. (2011) Am J Physiol Cell Physiol 300, C755-70.
2. Ghezzi, C. and Wright, E.M. (2012) Am J Physiol Cell Physiol 303, C348-54.
3. Wells, R.G. et al. (1992) Am J Physiol 263, F459-65.
4. Wright, E.M. (2001) Am J Physiol Renal Physiol 280, F10-8.
5. Lee, H. et al. (2012) Pediatr Nephrol 27, 1091-5.
6. Andrianesis, V. and Doupis, J. (2013) Expert Rev Clin Pharmacol 6, 519-39.
7. Sheridan, C. (2012) Nat Biotechnol 30, 899-900.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not
aliquot the antibody.