GIMAP5 Antibody

• 产品编号：CST-14108S      品牌：CST       原厂货号：14108S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Specificity / Sensitivity

GIMAP5 Antibody recognizes endogenous levels of total GIMAP5 protein. This antibody also recognizes proteins of unknown origin at 12 kDa and 50 kDa.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human GIMAP5 protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Specificity / Sensitivity

GIMAP5 Antibody recognizes endogenous levels of total GIMAP5 protein. This antibody also recognizes proteins of unknown origin at 12 kDa and 50 kDa.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human GIMAP5 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

GTPase immune-associated proteins (GIMAP), also known as immune-associated nucleotide-binding (IAN) proteins, are evolutionarily conserved GTP-binding proteins involved in lymphocyte development, inflammation, and autoimmune diseases (reviewed in 1,2). Human GTPase IMAP family member 5 (GIMAP5, hIan5) is the homolog of the rat Ian4 protein that is mutated in severe cases of T-cell lymphopenia and insulin-dependent diabetes in Biobreeding diabetes-prone (BB-DP) rats (3,4). GIMAP5 protein is preferentially expressed in CD4- and CD8-positive T-cells as well as B-cell lymphomas (4). Research studies using GIMAP5-deficient mice show that GIMAP5 protein is critical for survival of peripheral T-cells, hematopoietic stem cells, and progenitor cells (5-7). Additional studies indicate that GIMAP5 deficiency leads to a loss of immunological tolerance (8). Polymorphisms in the human GIMAP5 gene are associated with systemic lupus erythematosus and type I diabetes (9-11). Potential mechanisms for GIMAP5 control of cell survival include regulation of Bcl-2 family proteins, mitochondrial integrity, lysosomal function, and calcium regulation (7, 12-15).

1. Nitta, T. and Takahama, Y. (2007) Trends Immunol 28, 58-65.
2. Ciucci, T. and Bosselut, R. (2014) Eur J Immunol 44, 348-51.
3. Hornum, L. et al. (2002) Diabetes 51, 1972-9.
4. Zenz, T. et al. (2004) Genes Immun 5, 109-16.
5. Pandarpurkar, M. et al. (2003) Proc Natl Acad Sci U S A 100, 10382-7.
6. Schulteis, R.D. et al. (2008) Blood 112, 4905-14.
7. Chen, Y. et al. (2011) J Exp Med 208, 923-35.
8. Aksoylar, H.I. et al. (2012) J Immunol 188, 146-54.
9. Hellquist, A. et al. (2007) J Med Genet 44, 314-21.
10. Shin, J.H. et al. (2007) Genes Immun 8, 503-12.
11. Lim, M.K. et al. (2009) Lupus 18, 1045-52.
12. Keita, M. et al. (2007) Biochem Biophys Res Commun 361, 481-6.
13. Wong, V.W. et al. (2010) Self Nonself 1, 259-268.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not
aliquot the antibody.