CDIP Antibody

• 产品编号：CST-13824S      品牌：CST       原厂货号：13824S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Homology

Species predicted to react based on 100% sequence homology: Mouse, Rat

Specificity / Sensitivity

CDIP Antibody recognizes endogenous levels of total CDIP protein. This antibody may detect proteins of unknown origin at 35 and 70 kDa in some cell lines.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDIP protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Mouse, Rat

Specificity / Sensitivity

CDIP Antibody recognizes endogenous levels of total CDIP protein. This antibody may detect proteins of unknown origin at 35 and 70 kDa in some cell lines.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDIP protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Cell Death Involved p53-Target (CDIP) is a pro-apoptotic protein induced by genotoxic stress in a p53-dependent manner (1). Indeed, CDIP is a direct target of p53. Inhibition of CDIP impairs p53-mediated apoptosis. Induction of apoptosis by CDIP requires caspase-8 suggesting involvement in the extrinsic apoptotic pathway. CDIP also promotes increased expression of TNF-α capable of triggering apoptosis. Furthermore, expression of CDIP correlates with increased sensitivity of TNF-α-induced apoptosis (2). These studies suggest that CDIP may serve as a marker for apoptotic sensitivity.

1. Brown, L. et al. (2007) EMBO J 26, 3410-22.
2. Brown-Endres, L. et al. (2012) Cancer Res 72, 2373-82.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody