CD102/ICAM-2 (D7P2Q) Rabbit mAb

• 产品编号：CST-13355S      品牌：CST       原厂货号：13355S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

CD102/ICAM-2 (D7P2Q) Rabbit mAb可以识别内源性总的CD102 (ICAM-2)蛋白。单克隆抗体由合成肽段免疫动物产生，该肽段与人CD102 (ICAM-2)蛋白氨基末端附近氨基酸序列一致。细胞间黏附分子2（CD102/ICAM-2)是属于黏附分子免疫球蛋白超家族(IgSF)的一种细胞表面糖蛋白。和CD54/ICAM-1相似，CD102/ICAM-2是配体结合的白细胞粘附分子LFA-1（白细胞功能相关抗原-1），其介导的免疫细胞和其他细胞类型之间的细胞间的相互作用(1)。已经证明CD102/ICAM-2的表达会影响血管生成(2),细胞抗辐射（3）与抗肿瘤免疫应答(4)。CD102/ICAM-2和CD54/ICAM-1一起，介导T细胞爬行和血细胞渗出穿过血 - 脑屏障（5），以及跨支气管上皮细胞T细胞的迁移(6)。CD102/ICAM-2和肌动蛋白丝细胞骨架通过α-actinin的相互作用已经显示出能够限制神经母细胞瘤细胞的运动性(7),这个影响是依赖于CD102/ICAM-2的糖基化的(8)。

1. Staunton, D.E. et al. (1989) Nature 339, 61-4.
2. Huang, M.T. et al. (2005) Blood 106, 1636-43.
3. Ishigami, T. et al. (2008) Br J Cancer 98, 1357-65.
4. Hiraoka, N. et al. (2011) Gastroenterology 140, 310-21.
5. Steiner, O. et al. (2010) J Immunol 185, 4846-55.
6. Porter, J.C. and Hall, A. (2009) FASEB J 23, 492-502.
7. Yoon, K.J. et al. (2008) PLoS One 3, e3629.
8. Feduska, J.M. et al. (2013) BMC Cancer 13, 261.

原厂资料：

Specificity / Sensitivity

CD102/ICAM-2 (D7P2Q) Rabbit mAb recognizes endogenous levels of total CD102 (ICAM-2) protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CD102 (ICAM-2) protein.

Background

Intercellular cell adhesion molecule-2 (CD102/ICAM-2) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily (IgSF) of adhesion molecules. Like CD54/ICAM-1, CD102/ICAM-2 is a ligand that binds the leukocyte adhesion molecule LFA-1 (leukocyte function-associated antigen-1), which mediates intercellular interactions between immune cells and other cell types (1).

Expression of CD102/ICAM-2 has been shown to affect angiogenesis (2), cellular radioresistance (3) and anti-tumor immune response (4). Along with CD54/ICAM-1, CD102/ICAM-2 mediates T cell crawling and diapedesis across the blood-brain barrier (5), as well as T cell migration across the bronchial epithelium (6). CD102/ICAM-2 interaction with the actin cytoskeleton through α-actinin has been shown to limit the mobility on neuroblastoma cells (7), and this effect is dependent on glycosylation of CD102/ICAM-2 (8).

1. Staunton, D.E. et al. (1989) Nature 339, 61-4.
2. Huang, M.T. et al. (2005) Blood 106, 1636-43.
3. Ishigami, T. et al. (2008) Br J Cancer 98, 1357-65.
4. Hiraoka, N. et al. (2011) Gastroenterology 140, 310-21.
5. Steiner, O. et al. (2010) J Immunol 185, 4846-55.
6. Porter, J.C. and Hall, A. (2009) FASEB J 23, 492-502.
7. Yoon, K.J. et al. (2008) PLoS One 3, e3629.
8. Feduska, J.M. et al. (2013) BMC Cancer 13, 261.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.