LAMTOR4/C7orf59 (D4P6O) Rabbit mAb

• 产品编号：CST-13140S      品牌：CST       原厂货号：13140S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

LAMTOR4/C7orf59 (D4P6O) Rabbit mAb兔单抗可以识别内源性总的LAMTOR4 (C7orf59)蛋白。单克隆抗体由合成肽段免疫动物产生，该肽段与人LAMTOR4 (C7orf59)蛋白的羧基端邻近残基序列一致。后内体/溶酶体接头和MAPK和MTOR激活子4(LAMTOR4)是C7orf59基因编码的调节蛋白复合物的重要成分（1）。调节蛋白复合物也包括LAMTOR1/C11orf59, LAMTOR2/ROBLD3, LAMTOR3/MAPKSP1,和HBXIP (1,2). 该五聚体蛋白复合物位于溶酶体膜，它对于Rag GTPases和mTORC1在溶酶体内的定位以及氨基酸信号激活mTORC1通路是必须的（1-3）。

1. Bar-Peled, L. et al. (2012) Cell 150, 1196-208.
2. Sancak, Y. et al. (2010) Cell 141, 290-303.
3. Zoncu, R. et al. (2011) Science 334, 678-83.

原厂资料：

Specificity / Sensitivity

LAMTOR4/C7orf59 (D4P6O) Rabbit mAb recognizes endogenous levels of total LAMTOR4 (C7orf59) protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LAMTOR4 (C7orf59) protein.

Background

Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 (LAMTOR4) is an essential component of the ragulator protein complex that is encoded by the C7orf59 gene (1). The ragulator complex also includes LAMTOR1/C11orf59, LAMTOR2/ROBLD3, LAMTOR3/MAPKSP1, and HBXIP (1,2). This pentameric protein complex localizes to the lysosomal membrane and is essential for the lysosomal localization of Rag GTPases and mTORC1 as well as the subsequent activation of mTORC1 in response to amino acid signaling (1-3).

1. Bar-Peled, L. et al. (2012) Cell 150, 1196-208.
2. Sancak, Y. et al. (2010) Cell 141, 290-303.
3. Zoncu, R. et al. (2011) Science 334, 678-83.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.