Catalase (D4P7B)?XP? Rabbit mAb

• 产品编号：CST-12980P      品牌：Cell Signaling Technology       原厂货号：12980P
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Catalase (D4P7B) XP® Rabbit mAb兔单抗可以识别内源性过氧化氢酶总水平。单克隆抗体由合成肽段免疫动物产生，该肽段与人过氧化氢酶蛋白羧基端附近氨基酸一致。过氧化氢酶催化将过氧化氢转换成水和氧气的化学反应(1)。研究表明这种抗氧化酶的过表达会增加胰岛β细胞清除活性氧簇的能力，从而保护胰岛β细胞免受氧化应激的破坏(2)。胰岛β细胞过表达这种酶还可以使之免受过氧化氢介导的脂毒性破坏，进一步表明该酶可能在糖尿病的发病中发挥着某些作用(3)。

1. Chelikani, P. et al. (2004) Cell Mol Life Sci 61, 192-208.
2. Chen, H. et al. (2005) Diabetes 54, 1437-46.
3. Elsner, M. et al. (2011) Diabetes 60, 200-8.

原厂资料：

Specificity / Sensitivity

Catalase (D4P7B) XP^® Rabbit mAb recognizes endogenous levels of total catalase protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human catalase protein.

Background

Catalase catalyzes the conversion of hydrogen peroxide to water and oxygen (1). Research studies show that overexpression of this antioxidant enzyme increases the ability of pancreatic β-cells to scavenge reactive oxygen species (ROS), thereby protecting pancreatic β-cells from oxidative stress (2). The pancreatic β-cells overexpressing this enzyme are also protected from hydrogen peroxide-mediated lipotoxicity, providing further evidence for the importance of catalase in the pathogenesis of diabetes (3).

1. Chelikani, P. et al. (2004) Cell Mol Life Sci 61, 192-208.
2. Chen, H. et al. (2005) Diabetes 54, 1437-46.
3. Elsner, M. et al. (2011) Diabetes 60, 200-8.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody