RAIG1 (D4S7D) XP? Rabbit mAb

• 产品编号：CST-12968P      品牌：Cell Signaling Technology       原厂货号：12968P
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

RAIG1 (D4S7D) XP^® Rabbit mAb兔单抗可以识别内源性的总RAIG1蛋白。此单克隆抗体由合成肽段免疫动物产生，该肽段与人RAIG1蛋白Val295邻近氨基酸序列一致。

维甲酸诱导基因1(RAIG1),也被称为RAI3和GPRC5A，属于G蛋白偶联受体(GPCRs)家族。GPCRs是哺乳动物中最大，数目最多的受体家族，由超过一千个成员组成(1)。 视黄酸（RA）是一组多效性信号分子，调节范围广泛的生理和发育过程。RAIG1被认为是RA信号的下游靶点(2)。RAIG1在肺组织和多种肺癌细胞系中表达，编码一个七次跨膜的糖蛋白，该糖蛋白被认为是一个肺癌抑癌基因(3,4)。

1. Jörissen, H. et al. (2009) BMC Cancer 9, 200.
2. Xu, J. et al. (2005) Am J Respir Cell Mol Biol 32, 381-7.
3. Veling, G. et al. (1992) Kinderkrankenschwester 11, 118-20.
4. Ye, X. et al. (2009) Cancer Biol Ther 8, 951-62.

原厂资料：

Specificity / Sensitivity

RAIG1 (D4S7D) XP^® Rabbit mAb recognizes endogenous levels of total RAIG1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val295 of human RAIG1 protein.

Background

Retinoic Acid-Induced Gene 1 (RAIG1), also called RAI3 and GPRC5A, belongs to the family of G protein-coupled receptors (GPCRs). GPCRs are the largest and most abundant receptor family in mammals, composed of more than one thousand members (1). Retinoic acids (RA) are a group of pleiotropic signaling molecules that regulate a broad range of physiologic and developmental processes. It is thought that RAIG1 may be a downstream target of RA signaling (2). RAIG1 is expressed in lung tissue and in several lung cancer cell lines, and encodes a seven-transmembrane glycoprotein presumed to be a lung tumor suppressor gene (3,4).

1. Jörissen, H. et al. (2009) BMC Cancer 9, 200.
2. Xu, J. et al. (2005) Am J Respir Cell Mol Biol 32, 381-7.
3. Veling, G. et al. (1992) Kinderkrankenschwester 11, 118-20.
4. Ye, X. et al. (2009) Cancer Biol Ther 8, 951-62.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.