MEIS1/2 Antibody

产品编号：CST-12744S 品牌：CST 原厂货号：12744S
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

–20°C.

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描述：

Homology

Species predicted to react based on 100% sequence homology: Mouse

Specificity / Sensitivity

MEIS1/2 Antibody recognizes transfected levels of total MEIS1 and MEIS2 proteins.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MEIS1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Mouse

Specificity / Sensitivity

MEIS1/2 Antibody recognizes transfected levels of total MEIS1 and MEIS2 proteins.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MEIS1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Hox, Pbx, and Meis are families of transcription factors that bind DNA via their homeodomains. Members from each family form heterodimers to give rise to complexes with unique DNA binding specificities. Homeodomain containing proteins are frequently involved in normal developmental processes, but can also be associated with tumorigenic states (1). MEIS proteins belong to the TALE (Three Amino Acid Loop Extension) homeobox containing transcription factor family. MEIS1 has been associated with leukemogenesis and neuroblastoma (2,3) while MEIS2 is known to play an important role in the transcriptional program that is induced in normal pancreatic development (4) and cardiogenesis (5).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.