LAMTOR4/C7orf59 (D6A4V) Rabbit mAb

• 产品编号：CST-12284S      品牌：CST       原厂货号：12284S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

LAMTOR4/C7orf59 (D6A4V)Rabbit mAb兔单抗可以识别内源性总的LAMTOR4/C7orf59 (D6A4V)蛋白。单克隆抗体由合成肽段免疫动物产生，该肽段与人LAMTOR4/C7orf59蛋白的羧基端邻近残基序列一致。LAMTOR4/C7orf59是Ragulator复合物的重要组分（1）。Ragulator也由LAMTOR1/C11orf59, LAMTOR2/ROBLD3, LAMTOR3/MAPKSP1, 和HBXIP (1,2)组成。该复合物位于溶酶体膜，对于溶酶体上的Rag GTPases和mTORC1定位以及mTORC1对氨基酸的应激反应至关重要（1-3）。

1. Bar-Peled, L. et al. (2012) Cell 150, 1196-208.
2. Sancak, Y. et al. (2010) Cell 141, 290-303.
3. Zoncu, R. et al. (2011) Science 334, 678-83.

原厂资料：

Specificity / Sensitivity

LAMTOR4/C7orf59 (D6A4V) Rabbit mAb recognizes endogenous levels of total LAMTOR4/C7orf59 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LAMTOR4/C7orf59 protein.

Background

LAMTOR4/C7orf59 is an essential component of the Ragulator complex (1). Ragulator also consists of LAMTOR1/C11orf59, LAMTOR2/ROBLD3, LAMTOR3/MAPKSP1, and HBXIP (1,2). This complex localizes to the lysosomal membrane and is essential for the lysosomal localization of Rag GTPases and mTORC1 as well as the subsequent activation of mTORC1 in response to amino acids (1-3).

1. Bar-Peled, L. et al. (2012) Cell 150, 1196-208.
2. Sancak, Y. et al. (2010) Cell 141, 290-303.
3. Zoncu, R. et al. (2011) Science 334, 678-83.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.