MAG (D10H1) Rabbit mAb

• 产品编号：CST-12275S      品牌：CST       原厂货号：12275S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

MAG (D10H1) Rabbit mAb兔单抗能够检测内源性的MAG总蛋白。该单克隆抗体是由合成的人源MAG蛋白脯氨酸(70位)肽段免疫动物而制备的。该单克隆抗体是由合成的人源MAG蛋白脯氨酸(70位)肽段免疫动物而制备的。

1. Li, M. et al. (1996) J Neurosci Res 46, 404-14.
2. Nguyen, T. et al. (2009) J Neurosci 29, 630-7.
3. Yamashita, T. et al. (2002) J Cell Biol 157, 565-70.
4. Mehta, N.R. et al. (2010) ACS Chem Neurosci 1, 215-222.

原厂资料：

Specificity / Sensitivity

MAG (D10H1) Rabbit mAb recognizes endogenous levels of total MAG protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro70 of human MAG protein.

Background

Myelin-associated glycoprotein (MAG), which contains five immunoglobulin-like domains, is a highly glycosylated protein (1). MAG is a component of all myelinated internodes, whether formed by oligodendrocytes in the central nervous system (CNS) or by Schwann cells in the peripheral nervous system (PNS) (2), and has several functions. A known function of MAG is its inhibition of axonal regeneration after injury. It inhibits axonal outgrowth from adult dorsal root ganglion and in postnatal cerebellar, retinal, spinal, hippocampal, and superior cervical ganglion neurons (3). Interaction between MAG and several other molecules on the innermost wrap of myelin and complementary receptors on the opposing axon surface are required for long-term axon stability. Without MAG, myelin is still expressed, but long-term axon degeneration and altered axon cytoskeleton structure can be seen (4).

1. Li, M. et al. (1996) J Neurosci Res 46, 404-14.
2. Nguyen, T. et al. (2009) J Neurosci 29, 630-7.
3. Yamashita, T. et al. (2002) J Cell Biol 157, 565-70.
4. Mehta, N.R. et al. (2010) ACS Chem Neurosci 1, 215-222.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.