SSTR1 Antibody

• 产品编号：CST-11830S      品牌：CST       原厂货号：11830S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

SSTR1 Antibod兔多抗能够检测内源性的SSTR1总蛋白。该多克隆抗体是由合成的人源SSTR1蛋白缬氨酸(365位)肽段免疫动物而制备的。抗体由protein A和肽亲和层析技术纯化。

生长素受体是G蛋白偶联受体超家族的一员。已克隆了五种编码生长抑素受体的基因（SSTR1，SSTR2A SSTR2B，SSTR3，SSTR4和SSTR5），它们编码六个不同的蛋白亚型（1）。生长抑素受体被生长抑素激活，后者是大脑中的一种神经肽，作为一种神经递质调节内分泌组织的激素分泌（2）。生长抑素受体被发现在人体神经内分泌肿瘤中高表达（3）。

1. Patel, Y.C. (1999) Front Neuroendocrinol 20, 157-98.
2. Tulipano, G. and Schulz, S. (2007) Eur J Endocrinol 156 Suppl 1, S3-11.
3. Hofland, L.J. and Lamberts, S.W. (2003) Endocr Rev 24, 28-47.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Human, Mouse, Monkey

Specificity / Sensitivity

SSTR1 Antibody recognizes endogenous levels of total SSTR1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val365 of human SSTR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Somatostatin receptors are part of the super family of G protein-coupled receptors. Five genes encoding six different somatostatin receptor subtypes (SSTR1, SSTR2A, SSTR2B, SSTR3, SSTR4, and SSTR5) have been cloned (1). Somatostatin receptors are activated by somatostatin, a neuropeptide that acts as a neurotransmitter in the brain that regulates hormone secretion from endocrine tissues (2). Somatostatin receptors are found to be highly expressed on human neuroendocrine tumors (3).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.
*Species cross-reactivity is determined by western blot.
** Anti-rabbit secondary antibodies must be used to
detect this antibody.
Recommended Antibody Dilutions:
Western blotting 1:1000