Description: The human sCD80 Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD80. The human sCD80 Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures.
CD80 is a costimulatory molecule that serves as the ligand for two molecules expressed on T lymphocytes, CD28 and CTLA-4. The cell-surface molecule is found only on antigen-presenting cells. It mediates critical T-cell inhibitory signals. Like CD86, CD80 is a type I glycoprotein made up of two extracellular lg-like domains, a transmembrane region and a cytoplasmic tail. The N-terminal V-domain and the membrane-proximal C-domain share high homology to each other and the respective regions of lg’s.
The B7/CD28 CTLA-4 costimulatory pathway has been shown to play a critical role in determining the fate of immune responses, meaning activation versus down-regulation, and is a highly promising therapeutic target for treating autoimmune diseases. The regulatory roles of CD80 in autoimmune pathogenesis have been shown for a number of diseases like systemic lupus erythematosus and multiple sclerosis. It is furthermore a crucial molecule in transplantation biology.
Components
Aluminium pouch(es) with a Microwell Plate coated with Monoclonal Antibody (murine) to human sCD80 and HRP-Conjugate (anti human sCD80 monoclonal antibody), and Sample Diluent lyophilized
Aluminium pouch(es) with a human sCD80 Standard curve (coloured)
Wash Buffer Concentrate 20x (phosphate-buffered saline with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Sample Diluent (Use when an external predilution of the samples is needed.)
Stop Solution (1M Phosphoric acid)
Adhesive Plate Covers
京公网安备11010802025653 版权所有：北京逸优科技有限公司
