Description: The human sCD137 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD137. The human sCD137 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family, expressed on activated T lymphocytes. The expression of CD137 is strictly activation dependent in primary cells. Co-stimulation through CD137 enhances T lymphocyte activation and may enable rejection of tumors in vivo. The gene for human CD137 resides on chromosome 1q36, in a cluster of related genes, and this chromosomal region is associated with mutations in several malignancies.
Soluble forms of members of the TNF receptor family have been demonstrated for the various members. The soluble isoforms of CD137, sCD137, are generated by differential splicing and can be detected at enhanced concentrations in sera of patients suffering from various diseases.
Components
Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human sCD137
Biotin-Conjugate anti-human sCD137 polyclonal antibody
Streptavidin-HRP
Human sCD137 Standard lyophilized, 100 ng/ml upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films
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