Signal transduction via nuclear hormone receptors is important for cell growth and differentiation, development, and homeostasis. Nuclear
hormone receptors are ligand-activated transcription factors that modulate target gene expression.These ligand/receptor complexes also
interact with transcriptional coactivators which enhance ligand-dependent transcription. Various classes of coactivators have been identified,
including SRC-1 and its related proteins, such as TIF-2/GRIP-1, RIP140, AIB-1, and TIF-1α and -1ß. SRC-1 is a member of the basic
helix-loop-helix-PAS domain family. It contains an N-terminal basic-helix-loop-helix (bHLH), two N-terminal PAS domains, and a
glutamine-rich region near the C-terminus. SRC-1 interacts with many different steroid receptors and recruitment of SRC-1 to promoter sites
may facilitate opening of chromatin structure via its histone acetyltransferase activity, as well as stabilization of the preinitiation complex.
ERK-2 can phosphorylate SRC-1 at threonine and serine sites in vitro. In addition, SRC-1 expression in cells stimulated with EGF enhances
progesterone receptor-mediated activation of a target reporter gene. Thus, SRC-1 is an important transcriptional co-activator involved in
steroid receptor signaling.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.This antibody has been developed and certified for the bioimaging application. However, a routine bioimaging test is not performed on every lot. Researchers are encouraged to titrate the reagent for optimal performance.
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