B-Raf Pure 13/B-Raf 50ug

产品编号：BD-612374 品牌：BD-Pharmingen 原厂货号：612374
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

The Raf kinase family, A-Raf, B-Raf, and C-Raf, act as downstream effectors for Ras. These ser/thr kinases have homologous kinase domains

referred to as conserved regions (CR1, CR2, and CR3). Rafs have a critical role in the response to many growth factors including: EGF,

PDGF, insulin, IL-2, IL-3, CSF-1, and GM-CSF. Raf can directly interact with Ras-GTP and subsequently become activated. This leads to Raf

activation of the MAP kinase pathway by phosphorylating and activating MEK, which then phosphorylates and activates MAP kinaes (ERK).

A-Raf is a proto-onocogene that is highly expressed in urogenital and kidney tissues while B-Raf is expressed at high levels in cerebrum and

testes. C-Raf appears to be uniformly and ubiquitously expressed. Cell transformation by A-Raf has been shown to be independent of p21ras,

suggesting the possibility of an independent signal transduction pathway. B-Raf is expressed as multiple isoforms that range from 69-72 kDa

and 79-99 kDa. In hematopoietic cells, B-Raf is activated by EPO, GM-CSF, and SCF. Thus, the Raf kinases are important Ras effectors

involved in growth factor signaling in a wide variety of cells and tissues.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.