Nicastrin Pure 35/Nicastrin 50ug

产品编号：BD-612290 品牌：BD-Pharmingen 原厂货号：612290
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

Amyloid precursor protein (APP) gene encodes multiple APPs ranging from 695 to 770 amino acids. The unprocessed form of APP is a

putative cell surface receptor that possesses neurite-promoting activity, and is involved in synaptic vesicle recycling. Processing of APP by

sequential enzymatic activity of β- and γ-secretase, and the presenilin proteins PS1 and PS2, produces APP fragments that may have unique

functions. β-secretase activity cleaves the extracellular portion of APP leading to asecreted APP form, while γ-secretase activity produces

β-Amyloid peptide (39-43 amino acids). The Aβ peptide produces abnormal plaques in the cerebral cortex and blood vesselwalls during

Alzheimer's disease. Nicastrin is a PS1 associated transmembrane protein,that contains N-terminal glycosylation and myristoylation sites.

Nicastrin can bind full length APP and the fragments produced by γ-secretase. In

C. elegans

, suppression of nicastrin expression produces

phenotypes that mimic those produced when notch signaling proteins are suppressed. In

Drosophila

, deficiencies in nicastrin prevent cleavage

of the intracellular portion of Notch. Thus, nicastrin may be a functional component of presenilins and γ-secretase complexes, which process

Notch and APP transmembrane receptors.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.