The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division. Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein. A family of N-terminal motor domain kinesin proteins includes KIF1A/1B, KIF3A/3B, KRP85/95, and Klp68d/64. KIF1A and KIF1B are 93% homologous in their N-terminal motor domains, however KIF1A contains a C-terminal PH domain. KIF1A and KIF1B are expressed in neurons where KIF1A is involved in fast anterograde axon transport of synaptic vesicles, and KIF1B is involved in anterograde axon transport of mitochondria. KIF1A associates with organelles that contain synaptotagmin, synaptophysin, and Rab3A. Disruption of the KIF1A gene in mice causes decreases in synaptic vesicle density, neuronal degeneration, and deficits in motor and sensory function. Thus, KIF1A is a critical brain motor protein involved with axonal transport of synaptic vesicle precursors.
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1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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