p21[Cdc42/Rac]-activated kinases (PAKs) bind and are activated by the small GTPases, Cdc42 and Rac. In yeast, the interaction of the PAK,
Shk1, with Skb1 (Shk1 kinase binding protein 1) is important in the regulation of cell morphology and mitosis. Skb1Hs, the human homolog
of Skb1, restores growth rates in yeast cells deficient for Skb1. Skb1Hs has also been identified as a 72 kDa pICln-binding protein (IBP72).
pICln is thought to be a cytosolic regulator of a swelling-induced chloride channel and interactions with Skb1Hs suggest a link with PAKs,
which are involved in cytoskeletal rearrangement. An additional line of study has identified Skb1Hs as a Jak binding protein (JBP1) via its
interactions with Jak1-3 and Tyk2. This study also identified Skb1Hs as a methyltransferase that interacts with multiple proteins which
possibly serve as physiological targets. Skb1Hs is expressed in a wide range of tissues and is thought to form homodimeric or multimeric
complexes. Thus, Skb1Hs (IBP72, JBP1) is a multifunctional protein that may participate in such diverse processes as transcriptional and
translational regulation, cytoskeletal rearrangement, and any of a number of signaling pathways.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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