Microsomal epoxide hydrolase (mEPHX/mEH/EPHX) is a bifunctional membrane protein that plays a role in the metabolism of reactive epoxide intermediates and in hepatocyte uptake of bile acids. mEPHX protein and nucleic acid sequence is evolutionarily conserved in human, rats, and rabbits and mEPHX protein expression is found in the embryo and multiple organs. Cellular expression of mEPHX has been localized to both the ER and sinusoidal plasma membrane. In the ER, mEPHX is expressed in two topological orientations. The type I orientated (Ccyt/Nexo) mEPHX remains in the ER, while the type II orientated (Cexo/Ncyto) mEPHX is localized to the plasma membrane. mEPHX metabolizes DMBA to both inert metabolites and metabolites that are electrophilic and possibly carcinogenic. mEPHX null-mice have been shown to be highly resistant to DMBA-induced carcinogenesis using skin cancer bioassays. Thus, mEPHX may have protective effects, such as bile acid uptake and reactive epoxide metabolism, as well as harmful effects related to the production of carcinogens.
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注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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