CD105 Pure 35/CD105 150ug

Endoglin (CD105), a major glycoprotein of human vascular endothelium, is a type I integral membrane protein with a large extracellular

region, a hydrophobic transmembrane region, and a short cytoplasmic tail. It also contains an RGD tripeptide that may be important for

cellular adhesion. There are two forms of endoglin (S-endoglin and L-endoglin) that differ in the length of their cytoplasmic tails. However,

the isoforms may have similar functional activity. When overexpressed in fibroblasts, both form disulfide-linked homodimers via their

extracellular domains. Endoglin binds TGF-β1 and TGF-β3 by associating with TGF-β type II receptor and binds BMP-7 by associating with

activin type II receptor. Thus, endoglin is an accessory protein of multiple TGF-β superfamily kinase receptor complexes. Loss of function

mutations in the human endoglin gene cause hereditary hemorrhagic telangiectasia, which is characterized by vascular malformations.

Deletion of endoglin in mice leads to death due to defective vascular development. Thus, endoglin is an endothelial specific cell surface

protein that may regulate angiogenesis through interactions with TGF-β superfamily kinase receptors.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.