Aralar Pure 8/Aralar 50ug

Mitochondria are the primary sites of ATP production within the cell. They contain two different membranes, the outer membrane and the

inner membrane. The outer membrane contains porins which form pores in the membrane and render it highly permeable. The inner

membrane is less permeable and contains a high protein-to-lipid ratio. This membrane contains a number of carrier proteins that mediate

metabolite transport. These belong to a superfamily of related proteins that are found in S. cerevisiae, C. elegans, and several mammalian

species. Aralar, a human member of this family, is expressed in the mitochondria within heart, skeletal muscle, and brain. Its C-terminal

half resembles proteins of the mitochondrial solute carrier superfamily and its N-terminal portion contains four putative Ca2+-binding

EF-hand domains. The presence of the EF-hands in Aralar make it a close relative of the large family of Ca2+-binding proteins that includes

calmodulin and myosin light chain. Aralar is thought to function as a Ca2+-regulated mitochondrial anion carrier or as a Ca2+ and anion

cotransporter since it is expressed primarily in tissues where cell function relies heavily on Ca2+- signaling.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.