Dynamins, phosphoproteins with intrinsic GTPase activities, play an important role during early endocytosis. The GTPase activity is
stimulated in vitro by microtubules, SH3 domain containing-proteins, and Protein Kinase (PKC)- mediated phosphorylation. Although highly
related, dynamins are differentially expressed in an organism. For instance, dynamin I is found only in the nervous system, dynamin II is
ubiquitously expressed, and dynamin III is located in lung, testis and brain. Due to four alternative splicing products for each of the dynamins,
the dynamin family contains at least 12 different members. The Dynamin Like Protein-1 (DLP1) is a new member of the dynamin family of
proteins. DLP1 (also known as DVLP) is widely expressed as two alternatively spliced products, each with different tissue expression
patterns. The larger product is about 84 kDa and reportedly found only in the brain, whereas the 79 kDa product is ubiquitously expressed.
Unlike dynamins I-III which co-localize with endocytotic vesicles, DLP1 is found aligned with microtubules and with the endoplasmic
reticulum, suggesting a secretory function for this novel protein.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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