Caspase-2/ICH-1L Pure 35 50ug

产品编号：BD-611022 品牌：BD-Pharmingen 原厂货号：611022
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

Caspase-2/ICH-1 is related to the C. elegans

cell death gene product CED-3 and its mammalian homologue interleukin-1β-converting enzyme

(ICE). Caspase-2 /ICH-1 was identified from a mouse cDNA library and originally termed NEDD-2. The NEDD-2 mRNA was found to be

expressed during early mouse embryonic brain development and subsequently down-regulated in adult neuronal tissue. With the identification

of the human NEDD-2 gene, the murine gene was renamed Ich-1 to symbolize Ice

and ced-3 homology. Caspase-2/ICH-1 mRNA is

alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as Caspase-2 long, or ICH-1L. The smaller

mRNA species encoding a protein of 312 amino acids is named Caspase-2 short, or ICH-1S. Overexpression of ICH-1L induces apoptosis,

while over-expression of Ich-1S suppresses Rat-1 cell death induced by serum deprivation. Thus, it appears that Caspase-2/ICH-1 plays an

important dual role in programmed cell death.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.