SIRP Alp 1 Pure 27/SIRP Alp1 50ug

产品编号：BD-611008 品牌：BD-Pharmingen 原厂货号：611008
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at -20°C.

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描述：

Protein tyrosine phosphatases participate in the intracellular signaling pathways of mitosis, differentiation, migration, survival, transformation,

and death. SHP-2, a SH-2 domain containing phosphotyrosine phosphatase, is a positive signal transducer of receptor tyrosine kinases (RTKs)

and cytokine receptors. SIRPs (Signal-Regulatory Proteins) were identified as a result of their association with SHP-2. The 15+ members of

this family consist of two subtypes based on the presence or absence of a cytoplasmic SHP-2-binding domain. SIRPα1 is a transmembrane

polypeptide substrate of activated RTKs. When tyrosine-phosphorylated, SIRPα1 binds SHP-2, SHP-1, Grb2 through an SH2 interaction. The

SIRP proteins also constitute a subfamily within the Ig superfamily because they contain transmembrane glycoproteins with three Ig-like

extracellular domains. Additionally, SIRPs' cytoplasmic tails contain two ITI (immunoreceptor tyrosine-based inhibition motifs). Although

SIRPs have been shown to inhibit signaling through RTKs, their function is yet to be determined.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.