GluR Dta2 Pure 48/GluR Dta2 50ug

产品编号：BD-611006 品牌：BD-Pharmingen 原厂货号：611006
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

Glutamate is a major excitatory neurotransmitter of the CNS. The diversity of glutamate is exemplified by two distinct groups of receptors:

ionotropic and metabotropic. Ionotroic receptors are ligand-gated cation channels. They can be subdivided into two classes: NMDA and

AMPA/kainate receptors. GluR δ2 exhibits only 25% amino acid identity to either ionotropic receptor type. It presents selective and abundant

exression in cerebellar Purkinje cells. It is targeted to a subset of Purkinje cell spines and is coexpressed with ionotropic receptors. GluR δ2 is

involved in motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression (LTD). The latter is a decrease in the

efficacy of the synaptic transmission between parallel fibers and Purkinje neurons and is a cellular basis of motor learning. In fact, mGluR

δ2-deficient mice lack LTD. Additionally, an amino acid substitution in transmembrane III of δ2 is responsible for the neurodegeneration seen

in Lurcher mice. This substitution is a gain of function mutation that results in disruption of Purkinje membrane potential. Thus, GluR δ2 is an

important regulatory component of the Purkinje GluR channel.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.