DNA-PKcs Pure 6/DNA-PKcs 50ug

• 产品编号：BD-610804      品牌：BD-Pharmingen       原厂货号：610804
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

DNA-PK is a trimeric enzyme that is composed of a catalytic subunit of ~ 465 kDa (DNA-PKcs) and a heterodimeric regulatory subunit of 70
kDa and 86 kDa. DNA-PKcs has been reported to be inactive alone and depends on the regulatory subunit for subcellular localization and
kinase activity. DNA-PKcs belongs to the phosphatidylinositol (PI)3-kinase family and phosphorylates proteins, particularly transcription
factors, but not lipids. It is most similar to the members of this family that regulate cell cycle control, DNA repair, and DNA damage.
DNA-PKcs and Ku80 are involved in V(D)J recombination and DNA double-stranded break repair mechanisms. The immunodeficiency
disorder SCID is the result of abnormal V(D)J recombination in T lymphocytes. In SCID mice, a portion of the DNA-PKcs C-terminal
phosphatidylinositol 3-kinase domain is deleted due to a T to A nucleotide transversion that produces a premature stop codon and a truncated
protein product. Thus, the mutated gene for DNA-PKcs may be the SCID gene.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.