AMPK Bta Pure 12/AMPKBta 50ug

• 产品编号：BD-610802      品牌：BD-Pharmingen       原厂货号：610802
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

AMP activated protein kinase (AMPK) was identified as a result of its phosphorylation and inactivation of lipid metabolism enzymes.
However, AMPK also phosphorylates enzymes involved in other metabolic pathways. AMPK is activated by AMPKK (AMPK Kinase)
-mediated phosphorylation in response to intracellular changes in AMP levels. Although rat skeletal muscle AMPK exists as a monomer,
active rat liver AMPK is a heterotrimer of α (catalytic subunit), β, and γ subunits. The catalytic subunit (63 kDa) is structurally and
functionally related to the S. cerevisiae SNF1 protein kinase, an enzyme that is required for expression of glucose repressed genes during
glucose starvation. AMPK β (38 kDa) is strongly related to SIP2 (35% identity) and contains a C-terminal region that is very homologous to
the SIP1/SIP2/GAL83 ASC domain. AMPK β has some identity (35%) with SNF4, which is necessary for SNF1 activation. Both AMPK β
and γ are widely expressed in rat tissues. AMPK β facilitates the interactions of the α and γ subunits in vitro. Although AMPK β is clearly
necessary for formation of the heterotrimeric complex, there are other probably, yet unknown, roles for this protein.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.