CuL-2 Pure 4/CUL-2 50ug

• 产品编号：BD-610778      品牌：BD-Pharmingen       原厂货号：610778
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul-2, C.elegans
Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of
both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. Abnormal nuclear localization of Cul-2 is seen in a rare hereditary
condition known as VHL (von Hippel-Lindau) syndrome. Patients with VHL syndrome possess a mutant VHL gene and develop cancers such
as retinal anginomas, CNS hemangioblastomas, and renal cell carcinomas. In normal cells, the VHL protein competes with subunit A of
elongin, a transcription elongation factor, for binding to subunits B and C. The formation of the VHL-B-C complex inhibits elongation.
Additional data indicates that this complex associates with CUL-2 and promotes CUL-2 nuclear translocation. In cells with mutated VHL,
transcriptional elongation is not efficiently curtailed and CUL-2 is not properly localized in the nucleus. Therefore, CUL-2 mediates VHL
function, suggesting CUL-2 may be a candidate human tumor suppressor.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.