MCC Pure 1/MCC 50ug

产品编号：BD-610740 品牌：BD-Pharmingen 原厂货号：610740
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

TheMutated inColorectalC

ancer gene (MCC) was identified as a tumor suppressor that is deleted in sporadic and familial colorectal cancers.

MCC is located at chromosome region 5q21. This region is often deleted in and associated with adenomas and carcinomas. Allele losses in the

regions contiguous to MCC correlate with a high rate of colorectal tumors. MCC has been reported to be widely expressed and most abundant

in epithelial cells and brain. It is a protein of 829 amino acids with a short sequence homologous to the m3 muscarinic acetylcholine receptor.

Immunolocalization studies show MCC in the lateral plasma membrane of intestinal epithelial cells. In brain, MCC is abundant in the

molecular layer of the cerebellum and is associated with various organelles, such as the plasma membrane. Although overexpression of wild

type MCC protein blocks progression through the cell cycle, a mutated MCC, that contains a Gln instead of Arg-506, does not. Therefore,

wild type MCC functions as a negative regulator of the cell cycle. Mutations or deletions in MCC might interfere with its physiological role

and allow unrestricted cell proliferation (i.e. tumor formation).

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.