Arginase I Pure 19/Arginase I 150ug

产品编号：BD-610709 品牌：BD-Pharmingen 原厂货号：610709
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

150ug

运保温度:

Store undiluted at -20° C.

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描述：

Arginase converts arginine into urea plus ornithine, the final step in urea synthesis. Two different isoforms (I&II) have been isolated with

approximately 60% homology at the nucleotide level. While type II is present in many tissues, Arginase I is expressed exclusively in liver. In

cultured macrophages, as well as in vivo, Arginase I is induced with nitric oxide synthase (NOS) and the arginase I transactivator C/EBPβ in

response to lipopolysaccharide. This response occurs in a dose and time-dependent manner. While the mRNA for NOS appears as early as 2h

after treatment, mRNA levels for arginase I peak after twelve hours of lipopolysaccharide treatment. Since the synthesis of nitric oxide by

NOS requires arginine, the delayed induction of arginase I may be necessary for the regulation of NOS activity.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.