Protein phosphatase 1 (PP1) is involved in protein synthesis, glycogen metabolism, cell division, and neuronal metabolism. PP1 contains a
catalytic subunit that is associated with a regulatory subunit (inhibitor 2), a G subunit, and an M subunit. Inhibitor 2 is a heat stable 205 amino
acid protein subunit of PP1 that inhibits the activity of the enzyme. Inhibitor 2 is phosphorylated by p90[rsk], MAP kinase, glycogen
synthase-3 (GSK-3), and casein kinase II. Phosphorylation of inhibitor 2 results in PP1 activation. It is thought that inhibitor 2 acts as a
chaperone for PP1 and prevents the unregulated dephosphorylation of cellular substrates.
原厂资料:
注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.