Abl and Disabled (Dab) are essential for correct axonal connections during Drosophila development. Mutations in Enabled (Ena) rescue the
genetic defects caused by mutated Abl and Dab. Mena (Mammalian Ena) is a protein with significant homology to Eva, VASP, and WASP
proteins. The murine Mena gene predicts a protein of 541 amino acids. However, two additional exons that could introduce 246 amino acids
onto the C-terminal region have been identified. Homology searches identified two EVH domains (Ena-Vasp homology), one near each
terminus of Mena. Antibodies to Mena detect 80 kDa, 88 kDa, and 140 kDa protein with the 80 kDa and 88 kDa proteins being widely
expressed and the 140 kDa protein reportedly mainly found in brain tissue. Like VASP, Mena is localized to focal contacts and, when
ectopically expressed, induces the formation of F-actin outgrowths in fibroblasts.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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