FKBP65 Pure 25/FKBP65 50ug

FK506, one of multiple potent compounds that block T cell proliferation, is used for immunosuppressive therapy. Several FK506-binding

proteins (FKBPs) have been identified in the search for intracellular targets for FK506. These include FKBP12, FKBP13, FKBP51, and

FKBP52. The immunosuppressive effects of FK506 and FKBPs result from the inhibition of the calcineurin phosphatase, a well known

component of the signaling cascade leading to IL-2 production. FKBP65 is another member of the FKBP protein family and contains the

characteristic peptidylprolyl cis-trans-isomerase activity. FKBP65 has been reported to be expressed in the lung, testis, brain, heart, and

spleen. Although it has a predicted molecular weight of 65 kDa, FKBP65 has been observed to migrate ranging from 68-72 kDa in SDS

electrophoresis gels, perhaps, due to glycosylation and/or phosphorylation.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.