Originally identified as the oligodendrocyte-specific glycoprotein J1-160/180, Janusin is a protein of 1356 amino acids found exclusively in the nervous system. It belongs to the family of extracellular matrix proteins that is similar to Tenascin. These proteins are important in maintaining the interactions between neurons and glial cells. The two different molecular sizes of Janusin result from alternative splicing of its mRNA. Although Tenascin is widely expressed, Janusin's mRNA expression peaks shortly after birth and is highest in the cerebellum, olfactory bulb, and hippocampus. Like Tenascin, Janusin has a fibrinogen-like domain, nine fibronectin type III domains, four epidermal growth factor-like repeats, and an amino terminal cystein-rich region.
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注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.