One of the most powerful effector mechanisms of the immune system is the reaction initiated by IgE-dependent tissue stimulation of mast cells and basophils. When antigen binds surface IgE on these cells, there is a rapid release of histamine and other mediators that collectively initiate immediate hypersensitivity. This effect is part of a larger response called the late phase reaction (LPR). An IgE-dependent Histamine Releasing Factor (HRF) is present in biological fluids of allergic patients. It causes the release of histamine in IgE-producing cell preparations, where non IgE-producing cells of the same origin do not release histamine. HRF has been reported to be observed as a 21 kDa or 23 kDa protein produced in mouse and human cell lines, respectively. Its sequence does not predict a secretory form, but HRF is found in biological fluids. Neither the exact function of this protein nor the method of its secretion is known.
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注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
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