Villin Pure 12/Villin 150ug

产品编号：BD-610359 品牌：BD-Pharmingen 原厂货号：610359
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at -20°C .

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描述：

	The isolated intestinal microvillus cytoskeleton (core) consists of four major proteins: actin, villin, fimbrin, and brush border myosin-I. These

proteins can assemble in vitro into structures resembling native microvillus cores. Of these components, villin, and brush border myosin-I

show tissue-specific expression, so they may be involved in the morphogenesis of intestinal microvilli. Found in association with the

microvillar actin bundles of the intestinal brush border, villin is a 95 kDa protein composed of two very similar domains of approximately 44

kDa each, the core, and a C-terminal domain of 8 kDa, the headpiece. The core has been shown to contain villin's Ca[2+] regulated capping,

nucleating, and severing activities, but it cannot induce the formation of microfilament bundles without the headpiece. Villin is a useful

differentiation marker of early embryogenesis and may be useful in diagnosis and follow-up of colorectal cancers. It has been demonstrated

that villin is necessary for both the cytoskeletal and membrane protein organization of a functional brush border.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .