ERK3 Pure 30 50ug

产品编号：BD-610105 品牌：BD-Pharmingen 原厂货号：610105
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at -20°C .

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描述：

	The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases)

	are activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to

	phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of

	proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well

	as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible

	for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK3 is a

	63kDa family member that is 43% homologous to ERK1 and ERK2. A 97kDa ERK3 isoform has also been described which possesses an

	additional 178 amino acids.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at -20°C .